Sheff Wed (10th place) v Middlesbrough (8)
Goalkeeper Keiren Westwood is not expected to return for Sheffield Wednesday due to a kidney problem but Michael Turner could make his debut after arriving from Norwich on loan this week.
Fellow defender Glenn Loovens is a doubt with a foot problem but striker Lucas Joao should be available after a hamstring complaint.
Middlesbrough head coach Aitor Karanka made seven changes for the Capital One Cup second-round victory at Burton in midweek, with one of them handing veteran defender Jonathan Woodgate his first appearance of the season.
He is likely to restore the bulk of those rested to the starting line-up.
Last season: Sheff Wed 2 Middlesbrough 0, Middlesbrough 2 Sheff Wed 3
Last five league matches: Sheff Wed D W L D D; Middlesbrough D D W D L
Top scorers: Moudou Sougou (Sheff Wed) 2; Christian Stuani (Middlesbrough) 4
Match odds: H 13-5 A 11-10 D 9-4
Referee: Mark Heywood (Cheshire)