A major retail development will go ahead after a High Court Judge refused an application against the scheme.
Work could start on the £20m project during summer this year – creating around 300 retail jobs and a significant number of construction jobs.
Threadneedle appealed against the plans to create a major retail development on the outskirts of Scunthorpe on the site of Trent Valley Garden Centre.
But this was refused by a High Court Judge in London today.
This followed a judicial review after the plans were twice passed by North Lincolnshire Council’s planning committee.
M&S (40,000 sq ft) is the flagship store and retail giants Debenhams (40,000 sq ft) will also be coming to Scunthorpe.
Work will start as early as the summer 2013 and is expected to be completed by Summer 2014.
To protect the town centre, under the Section 106 agreement, stores will not be able vacate the town centre for five years, with the exception of Boots as they have agreed to stay in the town centre.
Any protected species found on the site will be protected before work gets underway.
There will also be road improvements to help alleviate traffic congestion around the site.
Coun Liz Redfern, leader of North Lincolnshire Council, said: “This is a major milestone and I am delighted at today’s High court decision. It means that this major investment in retail development can finally get underway.
“Retail giants Debenhams and M&S have signed up with large stores and there’s set to be other stores including Boots.
“The development will create 300 much needed retail and a significant number of construction jobs and will attract shoppers far and wide.
“The development is set to bring around £20m into the North Lincolnshire economy that we are currently loosing as shoppers travel elsewhere. We have the necessary assurances, through signed legal agreements, to protect Scunthorpe Town Centre and to make the necessary road improvements to Doncaster Road, and I am confident that this development will be the catalyst to improving the prospects of our area.
“I’m excited that Scunthorpe will now get the boost it needs to drive the economy forward and attract more visitors to the area.”