Reports of a severe road incident on Mansfield Road have now been confirmed as a crash involving two vehicles.
No one is thought to be seriously injured in the crash which happened near The Embassy Club on Mansfield Road.
A spokesman for South Yorkshire Police said: "We have got one car that has gone over on its side. At this stage we have three motorists that have sustained injuries, none are looking particularly serious at this time.
"At least two of those will be taken to hospital, we are unsure about the third."
Mansfield Road is now closed between Woodhouse Lane and The Noah's Ark Pub.